News Summary
The Indianapolis Colts faced a tough loss against the Los Angeles Rams, ending their three-game winning streak with a final score of 27-20. Despite notable performances, including Tyler Warren’s first career touchdown, Daniel Jones struggled with two interceptions. Matthew Stafford shined for the Rams, throwing for 375 yards and securing a pivotal fourth-quarter comeback. The Colts, facing several key penalties and turnovers, now look ahead to their next challenge against the Las Vegas Raiders.
Indianapolis – The Indianapolis Colts suffered a disappointing defeat at the hands of the Los Angeles Rams, losing 27-20 in a closely contested match during Week 4 of the 2025 NFL season on September 28, 2025. This loss brings the Colts’ record to 3-1, ending their winning streak after three consecutive victories.
Despite the loss, Colts tight end Tyler Warren made a memorable mark by scoring his first career touchdown with a 2-yard rush. Warren also contributed with five receptions for 70 yards and participated in a wildcat formation during the game. Colts quarterback Daniel Jones threw for 262 yards, completing 24 of 33 passes, including one touchdown to Michael Pittman Jr.. However, Jones also faced challenges, throwing two interceptions that impacted the outcome of the game.
The Rams’ offense was led by quarterback Matthew Stafford, who completed 29 of 41 passes for an impressive 375 yards and three touchdowns. Puka Nacua, the Rams’ wide receiver, had an outstanding performance, catching 13 passes for 170 yards and one touchdown. Stafford’s performance also allowed him to achieve his 50th career fourth-quarter winning drive.
Key moments in the game included a 53-yard touchdown run by Colts running back Jonathan Taylor, which was nullified by a holding penalty against Adonai Mitchell. This setback was compounded by a critical fumble by Mitchell, who lost the ball out of the end zone when a touchdown appeared imminent. The Colts also faced several challenges with penalties, committing 11 infractions that resulted in a loss of 88 yards.
On the defensive side, the Colts managed to apply pressure with defensive tackle Adetomiwa Adebawore creating a fumble on Stafford at the Rams’ 17-yard line. The Colts’ special teams showcased strength as well, highlighted by a 56-yard punt from Rigoberto Sanchez. The Colts also successfully converted a 38-yard field goal by kicker Spencer Shrader.
The Colts’ defense and special teams played crucial roles in keeping the game competitive, but they ultimately struggled to overcome the offensive prowess of the Rams. The loss to Los Angeles serves as a reminder of the challenges that lie ahead as the Colts prepare to host the Las Vegas Raiders in Week 5.
This matchup displayed the mixed fortunes of the Colts’ strategy and player performances, highlighting both struggles and successes that contributed to the tight scoreline but ultimately led to their defeat.
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Additional Resources
- Colts.com: Tyler Warren’s First NFL Touchdown
- NFL.com: Tyler Warren’s Touchdown via Rush Attempt
- IndyStar: Colts vs Rams Live Game Coverage
- Colts.com: Tyler Warren’s Versatility Shines
- Fox Sports: Game Highlights
- Wikipedia: National Football League
- Google Search: Indianapolis Colts 2025 Season
- Google Scholar: Indianapolis Colts
- Encyclopedia Britannica: National Football League
- Google News: Colts vs Rams Week 4 2025

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